Publications
2026:
Mortimer, J.; Musacchio, P. Z.*
Acc. Chem. Res. (2026) 59 (15): 2538–2547
8. Harnessing Alkyl C–X Synthons for Constructing Vicinal Complexity via Alkene Radical Cations
Zhang, Y.; Das, T.; Xuan, Z.; Das, M.; Bisiriyu, H. O.; Nudler, A.; Parasch, B. D.; Resmini, M. D.; Graham, A. E.; Watson, D. F.; Hirschi, J. S.*; Musacchio, P. Z.*
Science, eaef0766 (2026)
DOI:10.1126/science.aef0766 / ChemRxiv (preprint)
Highlighted in:
~BingUNews: Research: A new mechanism may shorten the time involved in drug discovery
~C&EN: Chemists get twice the reactivity from a single substitution handle
~UB News Center: Blue lights and textbook chemistry could help create complex drugs in fewer steps
~Chemistry World: Photoredox catalyst introduces two nucleophiles across a carbon–carbon bond at once
2025:
Fitzpatrick, N. A.†; Howarth, A. M.†, Skrzypek, G. J., Lee, J., Yayla, H. G., Musacchio, P. Z.*
Org. Lett.2025, 27, 6065–6070.
https://doi.org/10.1021/acs.orglett.5c01637
†= co-first author
2024:
6. Wireless microLED packed beds for scalable continuous multiphasic photochemistry
Lopez, E. D.; Musacchio, P. Z.; Teixeria, A. R.
Reaction Chemistry & Engineering2024, 9, 2963-2974.
https://doi.org/10.1039/D4RE00241E
2023:
5. Azolation of Benzylic C–H Bonds via Photoredox-Catalyzed Carbocation Generation
Das, M.; Zamani, L.; Bratcher, C.; Musacchio, P. Z.
Journal of American Chemical Society2023, 145, 3861–3868.
https://doi.org/10.1021/jacs.2c12850
4. Shining light on diselenide bonds
Fitzpatrick, N. A.; Musacchio, Z. P.
Nature Chemistry2023, 15, 163–164.
Nature Chemistry ‘News & Views’ for Nat. Comm.2022, 13, 6885.
2022:
3. A “one size fits all” ligand for photoredox and metallaphotoredox catalysis
Zamani, L.; Musacchio, Z. P.
Chem2022, 8, 9, 2324–2326.
Preview for Chem2022, 8, 9, 2419–2431.
2. A SN1 mechanistic approach to the Williamson ether reaction via photoredox
catalysis applied to benzylic C(sp3)–H bonds
Fitzpatrick, N. A.; Zamani, L.; Das, M.; Yayla, H. G.; Lall, M. S.; Musacchio, P. Z.
Tetrahedron 2022, 125, 132986
https://doi.org/10.1016/j.tet.2022.132986
Zhang, Y.; Fitzpatrick, N. A.; Das, M.; Bedre, I.; Yayla, H. G.; Lall, M. S.; Musacchio, P.Z.
Chem. Catalysis2022, 2, 292-308.
https://doi.org/10.1016/j.checat.2021.12.010
~highlighted by Dr. Thomas West in Nature Synthesis: “Removing Hydride”
~preview by G. A. Lutovsky and T. P. Yoon in Chem Catalysis: “A radical crossover into C–H functionalization”
~highlighted in Synform 2022: link
~featured on the cover of Chem Catalysis: link
Prior to WPI:
8. Profiling the proteome-wide selectivity of diverse electrophiles. P.R.A. Zanon, F. Yu, P.Z. Musacchio, L. Lewald, M. Zollo, K. Krauskopf, D. Mrdović, P. Raunft, T.E. Maher, M. Cigler, C. J. Chang, K. Lang, F.D. Toste, A.I. Nesvizhskii, S.M. Hacker. ChemRxiv. Preprint. https://doi.org/10.33774/chemrxiv-2021-w7rss-v2 Link
7. Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery. R.W. Pipal, K.T. Stout, P.Z. Musacchio, S. Ren, T.J.A. Graham, S. Verhoog, L. Gantert, T.G. Lohith, A. Schmitz, H.S. Lee, D. Hesk, E.D. Hostetler, I.W. Davies, D.W.C. MacMillan, Nature2021, 589, 542-547. Link
6. A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation A. H. Christian, S. Jia, W. Cao, P. Zhang, A. T. Meza, M. S. Sigman, C. J. Chang, F. D. Toste, J. Am. Soc.2019, 141, 0052. Link
5. A Radical Approach to the Copper Oxidative Addition Problem: Trifluoromethylation of Bromoarenes C.C. Le, T. Q. Chen, T. Liang, P. Zhang, D. W. C. MacMillan, Science2018, 360, 1010. Link
4. The merger of transition metal and photocatalysis (Review). J.R. Twilton, C. C. Le, P. Zhang, M. H. Shaw, R. W. Evans, D. W. C. MacMillan, Nat. Rev. Chem. 2017, 1, 0052. Link
3. Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross Electrophile Coupling P. Zhang, C. C. Le, D. W. C. MacMillan, J. Am. Chem. Soc. 2016, 138, 8084. Link
2. Concise Approach to 1,4-Dioxygenated Xanthones via Novel Application of the Moore Rearrangement A. L. Nichols, P. Zhang, S. F. Martin, Tetrahedron2012, 68, 7591. Link
1. General and Expedient Synthesis of 1,4-Dioxygenated Xanthones A. L. Nichols, P. Zhang, S. F. Martin, Org. Lett.2011, 13, 4696. Link